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KMID : 0882420100790010077
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Korean Journal of Medicine
2010 Volume.79 No. 1 p.77 ~ p.81
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Autologous peripheral blood stem cell transplantation with high-dose therapy for anaplastic large cell lymphoma with progressive myelofibrosis
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Lee Na-Ri
Song Eun-Kee
Yhim Ho-Young
Jang Kyu-Yun
Choi Sam-Im
Yim Chang-Yeol
Kwak Jae-Yong
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Abstract
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Myelofibrosis is a myeloproliferative neoplasm characterized by abnormal bone marrow megakaryocyte proliferation with reticulin and collagen fibrosis, leukoerythroblastosis, anemia, increased level of serum lactate dehydrogenase and splenomegaly. Myelofibrosis associated with malignant lymphoma is rare and survival rates appear to have been poor. Herein, we describe our experience in a patient who remained in complete remission with high-dose therapy (HDT) with autologous peripheral blood stem cell transplantation (PBSCT) for ALK-negative ALCL presenting with rapidly progressing myelofibrosis.
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KEYWORD
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Myelofibrosis, Anaplastic large cell lymphoma, Stem cell transplantation
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